Why premature babies' survival often depends on where they were born

Three-quarters of premature babies who die could have been saved with access to basic health care.

A premature baby wrapped in a pink blanket in Nigeria.

Baby Isha Ali Modu in the newborn intensive care unit (NICU) at Nelifa Keji Hospital, one day after her birth. | Nigeria 2024 © Colin Delfosse

Premature birth is the leading cause of death for children under 5 years old. It’s also quite common across the world—but the chance of survival depends on where a child was born. 

In low-income countries, an estimated half of all children born preterm will die, while nearly all would survive if they were born in a high-income country like the United States or Canada, according to the World Health Organization (WHO). Most of these deaths can be prevented with access to basic medical services during and after pregnancy—yet this care that is inaccessible in some communities, including many of the places where Doctors Without Borders/Médecins Sans Frontières (MSF) teams work around the world, such as Central African Republic (CAR) and Nigeria, where the mortality rate related to prematurity is 17 and 7 times higher than in Western Europe, respectively. 

Two premature babies born at Nilefa Keji Hospital in Nigeria.
Two babies born preterm at Nelifa Keji Hospital in Maiduguri, where MSF built a comprehensive emergency obstetric and newborn care facility. The child on the right is undergoing phototherapy. | Nigeria 2024 © Colin Delfosse

The facts about prematurity

 

Prematurity, or preterm birth, refers to children born alive before 37 complete weeks of pregnancy instead of the full pregnancy duration of 40 weeks. Prematurity can be categorized as ‘extremely preterm’ (before 28 weeks), ‘very preterm’ (28 to less than 32 weeks), or ‘moderate to late’ preterm (32 to 37 weeks).

Why is prematurity a concern worldwide?

There is still much research to be done to determine the causes and mechanisms that explain prematurity, including genetic factors. Research shows that some chronic conditions can be conducive to premature birth, such as diabetes, high blood pressure, infections (including some STDs), certain anomalies of the reproductive organs, having multiple pregnancies in a short period of time, delivering at a young age, and being pregnant with twins, triplets, or more. Other factors that could play a role in prematurity are smoking, drinking alcohol, using drugs, and even the effects of extreme heat. In addition, some pregnancy complications or infections require early induction of labor or a cesarean birth.

 A young pregnant woman in the triage area of the MSF-built comprehensive emergency obstetric and newborn care’ facility at the Nilefa Keji Hospital in Maiduguri, Borno state. This hospital is being run in collaboration with the state ministry of health.
A pregnant woman is checked in the triage area of the MSF-built maternal health facility at Nilefa Keji Hospital in Maiduguri, Borno state (left); a canula is inserted in a preterm baby’s hand (right). | Nigeria 2024 © Colin Delfosse

Where is prematurity most common?

The vast majority of preterm births occur in two regions: southern Asia and sub-Saharan Africa. In 2020, 45 percent of all preterm births occurred in just five countries: India, Pakistan, Nigeria, China, and Ethiopia.

The same year, an estimated 1.2 million preterm newborns were born in 10 of the most fragile countries affected by humanitarian crises: Afghanistan, Chad, CAR, Democratic Republic of Congo, Myanmar, Somalia, South Sudan, Sudan, Syria, and Yemen. In these areas, access to preventative and curative care for preterm babies can be extremely challenging. 

A premature baby is held in a "kangaroo pouch" at a hospital in Nigeria.

Nigeria 2024 © Colin Delfosse

Alima (left) holds her newborn niece in a “kangaroo pouch” that allows for extended skin-to-skin contact to improve her chance of survival. The baby’s mother died a day after giving birth to the baby girl preterm at 29 weeks, weighing just 3.3lbs. She spent two weeks in the NICU at Nilefa Keji Hospital as staff carefully monitored her vitals before being discharged under the care of her aunt, Alima.

The impact of premature birth on children

 

Early birth can pose serious health risks to a newborn baby as many organs are still growing and developing in the final weeks of pregnancy. Babies born preterm may face more direct health problems and often need to stay in the hospital longer, including in newborn intensive care units (NICUs). The earlier a baby is born, the more likely they are to have health problems. Premature babies may also be at risk of developing long-term consequences such as neurodevelopmental delays, vision and/or hearing impairment, chronic respiratory issues, behavioral and psychological effects, and growth and developmental delays.

In low-income countries, an estimated half of all children born preterm will die, while nearly all would survive if they were born in a high-income country, according to WHO.

Finding and treating health problems as early as possible—and preventing preterm birth when possible—can help babies lead longer, healthier lives. This calls for regular prenatal consultations to help identify risk factors and take action, as well as improving medical care during labor and birth, and adapted care for preterm babies. This is where the gap between high income and lower income countries is most striking.  

Dr. Amina Egujja holds a newborn after a cesarean section in the operating theater for obstetrics at Nilefa Keji Hospital
Dr. Amina Egujja holds a newborn after a cesarean section in the operating theater for obstetrics at Nilefa Keji Hospital, which is run in collaboration with the Ministry of Health. | Nigeria 2024 © Colin Delfosse

How MSF is helping premature babies

MSF teams around the world provide prenatal care, birth assistance, and postnatal care in places where the needs are greatest around the world, including in CAR and Nigeria, where our teams are supporting the ministries of health in improving preventative and curative services linked to prematurity. 

In CAR, where the mortality rate related to prematurity is 17 times higher than in Western Europe, MSF inaugurated a comprehensive emergency obstetric and neonatal care unit in 2022 in Bangui’s Centre Hospitalier Universitaire Communautaire. This MSF-supported 43-bed unit is the only facility in the capital providing free emergency obstetric and neonatal care.  

Jeanisse Ngaïdama, 23, gave birth to premature twins on October 11 in the MSF-supported specialized unit at the Centre Hospitalier Universitaire Communautaire in Bangui, the capital of the Central African Republic. On the picture, she is being followed up by Harouna Mouelle, nurse at the hospital.
Jeanisse gave birth to premature twins on October 11 in the MSF-supported specialized unit at the Centre Hospitalier Universitaire Communautaire in Bangui. | CAR 2024 © Evy Biramocko/MSF

In Nigeria, where the mortality rate related to prematurity is 7 times higher than in Western Europe, MSF teams provide support for a network of maternity units in Maiduguri and completed the construction of a hospital entirely dedicated to these services in June this year. This referral facility has been integrated into the public health system, with MSF teams training Ministry of Health personnel on patient care, including care for premature infants.

In both projects, MSF teams are using and teaching the “kangaroo care” method, an efficient method in which premature babies are held close to their mother’s bodies up to 24 hours a day, with exclusive breastfeeding. The prolonged skin-to-skin contact keeps them warm, provides constant connection, and ultimately reduces newborn illnesses while improving their chances of survival.